Penicillin G Procaine Fortified

Benzylpenicillin mixturesterile mixturePenicillin G Procaine / Potassium; 3:1

Penicillin G Procaine:

Molecular formula:
C16H18N2O4S.C13H20N2O2.H2O
Molecular weight:
588.7

Penicillin G Potassium:

Molecular formula:
C16H17N2O4S.K
Molecular weight:
372.5
 Procaine Fortified

Application

Sterile mixture of Penicillin G Procaine and Penicillin G Potassium, which can be filled into vials without adding any excipients. It complies with the BP-monograph "Fortified Procaine Penicillin Injection". A homogeneous solution is prepared by adding water for injection and shaking briefly.

Antibiotic category

One-day depot penicillin with elevated blood levels

Packaging

Storage

Store below 25°C,
Protect from light and moisture

Shelf life

48 months

Specification

Appearancewhite to cream-colored, crystalline powder
Injection testcorresponding (needle diameter: not more than 400 µm)
Water content
(Karl Fischer)		not more than 3.5 %
pH-value5.0 - 7.5
Sterility
(USP/Ph.Eur.)		sterile
Bacterial endotoxins
(LAL-test/USP)		not more than 0.010 EU/100 IU
Assay/Content
  • Penicillin G (HPLC):
    1050 - 1160 IU/mg
  • Penicillin G Procaine (HPLC):
    785 - 870 IU/mg

Pharmacopoeial quality

The mixture corresponds to BP; the active substances correspond to USP, BP, Ph.Eur.