Penicillin G Potassium

Benzylpenicillin Potassiumbuffered, sterile mixture

Molecular formula:
C16H17N2O4S.K
Molecular weight:
372.5
CAS registry no.:
113-98-4
 Potassium

Application

Sterile mixture of Penicillin G Potassium with approx. 4.6 % of sodium citrate buffer. The mixture can be filled into vials without adding any excipients.

Antibiotic category

Short-acting penicillin for high initial blood levels

Packaging

Storage

Store below 25°C,
Protect from light and moisture

Shelf life

36 months

Specification

Appearancewhite to whitish, crystalline powder
Loss on dryingnot more than 1.5 %
Fibers & suspended matterpractically free from fibers and suspended matter
Particulate matternot more than particle level 5
Clarity of solution
(3 g in 10 ml water)		clear (not more than 3.0 NTU)
pH-value6.0 - 8.0
Sterility
(USP/Ph.Eur.)		sterile
Bacterial endotoxins
(LAL-test/USP)		not more than 0.010 EU/100 IU
Largest impurity
(Ph.Eur./HPLC)		not more than 1.0 %
Assay
  • Penicillin G (HPLC):
    1355 - 1595 USP-U/mg
    81.4 - 89.8 % 1)
1) Based on the dried substance

Pharmacopoeial quality

The mixture corresponds to USP; the active substance corresponds to USP, BP, Ph.Eur.